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it's crazy how normalized spending 1k+ on a phone has become. I can't imagine paying that for a phone that is almost identical in features I care about to something 1/3 the price.


> All economic activity is a key driver to climate change

what a pointless thought-terminating cliché

> You're clearly imposing a self-serving moral judgement on other people.

Just because you are the wrong side of morality does not mean they are incorrect


your infinitesimally rare edge case is not a negation of the comment you are responding to. Also I don't think there is even any good evidence that some people have genetic heritage that means they can only eat animal foods


> They failed to stop capitalism

good thing, too!


as someone who has a good amount of experience with psychedelics - there is actually a surprising amount of overlap between the two experiences, but mostly in a generalized "how they can feel" way, and not in the sense that they are the same type of experience.


the literature is very clear about the relationship between high LDL and Atherosclerosis. Are you referring to poor health in general, separate from Cardiovascular Disease?


you didn't read the article did you? Or are you actually here to claim that people with hypercholesterolemia just need to eat better?

Do you have the same simplistic ideas about GLP-1's?


For all people? No. For the vast majority of people? Yes. Eat healthy and exercise more.


The dietary impact on cholesterol in the blood is surprisingly low. Looking it up, this source says diet can affect 20-30% of your blood levels [1]. I don’t have a great statistic about exercise, but I’d encourage you to question what you think you know — at the very least I’ll claim you’re mistaken about the importance of dietary impacts on cholesterol, which perhaps should give you pause about your other beliefs

[1] https://my.clevelandclinic.org/health/articles/16867-cholest...


Dietary cholesterol has little impact on blood cholesterol. However the post that started this debate mentioned mass loss. And that does have a decent correlation. Go from obese to not obese and the median person's cholesterol will drop quite a bit.


It’s possible the comments have changed, but I see nothing in the thread about mass loss. I do agree about weight though — losing weight is largely diet.

> Go from obese to not obese and the median person's cholesterol will drop quite a bit.

This is really interesting, I don’t think I’ve heard that before. Do you have a source you could share?

Edit: this doesn’t necessarily prove you wrong, but this paper argues there’s little correlation between bmi and cholesterol [1]

[1] https://link.springer.com/article/10.1007/s11695-010-0170-7


There isn't. I'm 15% body fat, eat healthy (avoid saturated fats, prioritize fiber), exercise 5-6 times per week, and have hypercholesterolemia. I, along with my parents, have very high LDL and ApoB and nothing I can do about it in terms of diet, exercise, or weight.

I'm also not uncommon. They suspect as much of 30% of the population could be like this. There's a lot of ignorance in this thread.


There's a difference between always being hypercholesterolemia as a fit person and being obese and losing a bunch of weight when it comes to these conversations.

It's one f those things where some people's "I can't help it!" claims are true, but many are not. That doesn't invalidate the first category even though most people in the category are in the latter.


> That doesn't invalidate the first category even though most people in the category are in the latter.

so you solved obesity then! people just need to make better choices! Glad we have you here solving the worlds greatest mysteries


for the most part mass == weight on Earth.

Triglycerides & HDL are affected by weight (tho more triglycerides than anything else), e.g. Wing 2011.


> for the most part mass == weight on Earth.

The thread above us discusses neither mass nor weight. Here it is copied in full -- I encourage you to use ctrl-f

> mediumsmart 1 hour ago

> One could eat healthy instead of course but hey, the good life.

> shlant 1 hour ago

> you didn't read the article did you? Or are you actually here to claim that people with hypercholesterolemia just need to eat better?

> Do you have the same simplistic ideas about GLP-1's?

> moi2388 1 hour ago

> For all people? No. For the vast majority of people? Yes. Eat healthy and exercise more

I'm a bit upset that I put in effort to genuinely engage in your claims, and you're not willing to go back and read the thread to confirm claims that _you made_. In fact, you suckered me into re-reading the same thread _for the third time_ looking for some throwaway line I missed about mass or weight. I could just decide that internet discussion doesn't matter, and stop engaging on HN, but I'd rather not do that. Can you please try a bit more?

I'm not going to reply to the Triglycerides & HDL comment without a link. It was your claim initially, and I was nice enough to provide a link with evidence against it, so surely you can do the same in support.


I was responding to the glp-1 question.

And yes, exercising and dieting absolutely reduces the need for these medications.

It also reduces the amount of people who have high cholesterol, although again, in both cases not all


Fiber intake has a dose-dependent effect on cholesterol levels.

Obviously some people still need medication if they have particularly unfortunate genetics.


wow you figured it out! but wait.. if it's that easy why is obesity such a huge issue?


I love that they made the comparison to Hacker News in terms of request sizes lmao. Yea definitely a representative sample


the vast majority of the anti-statin crowd are just regurgitating talking points they heard from people in their diet tribe - usually keto/carnivore


supposedly that comes mostly from observational studies whereas RCT's seem to show that at some point full regain will probably happen (although can take 1-2 years). The Observational studies don't seem to control for people stopping GLP-1's but still trying other drugs/weight loss methods which is where the discrepancy from RCT's seems to be.


> supposedly that comes mostly from observational studies whereas RCT's seem to show that at some point full regain will probably happen

Do you have one you’d recommend reading?


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