Someone I love dearly passed two weeks ago from this awful cancer. She was on a trial for this drug, but it was ineffective, sadly. I can't stop crying. This is a horrible disease and I am so glad there are developments being made in this to extend people's lives, possibly even save them.
An offline-first app to make life a little easier for someone I love and her caregiver. She's been diagnosed with stage 3 pancreatic cancer and food has been a bit of a nightmare for her. Her partner is also not very skilled with cooking, so helping them make this easier is my gift to them. Not a medical device, just a food logging and logistics tool. The privacy aspect of this is very important, so
I am so careful not to let anything not heavily encrypted touch a network request. Sync is opt-in, offline is default. This is very challenging for me, but I want to help her the best way I know: building software for humans.
Failing a treatment that has held promise for so many others and been heralded as paradigm-shifting is such a weird place to be. There's comfort in knowing others won't suffer, but loneliness is knowing you or a loved one still is.
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
While not fully approved, the company has early access available to people who meet the treatment criteria and would potentially benefit. Their HCP should evaluate this (it's not all types of pancreatic cancer, and it's not a silver bullet - but it looks like its double the survival time than current chemo). Hopefully this evolves into a new class of treatment.
Honestly. for the ~2 months my mum had between a totally out-of-the-blue stage 4 melanoma diagnosis and the day she died in the hospice, I don’t think there’s anything she would have wanted less than to endure more of that existence, if someone had offered her that pill.
I'm sorry your mom had to suffer like that :( My loved one really wants to live, and I suppose some people are at different stages of mind with this horrible disease. I wouldn't want to extend suffering too, but if the patient wants to fight the disease, it is up to them.
It's an extra 6 months or so, and it's almost certain a better solution won't be come available in that 6 months, and even if it did you are very close to death and unlikely to recover even if a miracle cure is developed. In the meantime you are in intense pain and suffering wild side effects.
I'm not yet financially comfortable, but once I am, this is definitely how I see my life going. I love my work, but I don't love the job, I've gotten burned out too many times.
For people who want some more freedom with their time, part time is ideal. I want to have more time to experiment and learn. Currently there is just no time for it.
It really puzzles me how people would just pop a pill instead of make some lifestyle changes. Maybe it's just my personality type, but it disturbs me how most people just want something quick and easy instead of doing the actual work and becoming overall better via a real learning journey by struggling through changing bad habits.
But whatever, they do whatever works for them! I don't like pharma.
Because when people say "just make some lifestyle changes," "just" is doing a lot of heavy lifting there.
Being fat really, really sucks, so most fat people have tried to make lifestyle changes, but they've gotten a lot of bad advice over the past half-century. They've cut back on fat, especially healthy animal fats, because that's what the government/medical/nutritional complex said to do, replacing them with "healthy grains," and only gotten fatter. They've tried to trim calories or portion sizes, which is difficult and ineffective for a lot of reasons. They've tried so-called weight-loss products promoted by corporations with millions to spend pushing them. They've thrown themselves into exercise plans, and while exercise is great for a lot of reasons, it doesn't have much effect on weight loss.
Even when they go outside the mainstream and try something that can actually work, like cutting carbs or fasting, it's difficult because losing weight isn't just the reverse of gaining weight. Fat cells aren't just buckets that fat falls into and can fall out of. Once energy is stored in the form of fat, it has to be burned to be removed, which requires a different set of hormones and enzymes than storing it did. Maintaining that metabolic mix generally requires an enormous amount of willpower, not just some lifestyle tweaks. People who have plenty of willpower to succeed in other areas of life like career or relationships can be defeated by it.
I don't like big pharma either, and I'm losing weight (slowly) with fasting rather than trying these drugs. But it's hard to blame people for using them, if it's a temporary fix and they're going to maintain their new weight through diet. I'm skeptical that it'll go that way for many, but I suppose there's hope.
I think I was a bit vague and blunt with my comment, and I agree with what you say here 100%
For me lifestyle changes weren't easy and as simple as "lifestyle changes". Lifestyle changes involved huge amounts of willpower, and still do to some extent. Nothing that's really valuable is possible with an easy way out. From personal experience, consistently doing something hard and building that habit is so much more sustainable long term than temporarily popping a pill and expecting the problem to stay away when they stop. I've known people who used Ozempic for some time, then stopped when they reached their goal weight, then just end up putting on that weight again. I don't blame Ozempic for it, it did its job well.
I was overweight, unhealthy and no amount of exercise and eating so-called "healthy low fat" dietician-recommended foods helped me get healthier and leaner. I had to let go of the beliefs I held about how nutrition should be. I don't blame anyone, I just find it personally puzzling that people don't seem to want to challenge the status quo because the status quo isn't working.
Fasting, low carbs and cutting out sugar completely has done so much good for me, not just on a weight loss level. It took years of self-education, figuring out what works for me and my body to get where I am now. Physical health probably isn't one of their top personal values. This goes deeper than just a simple "lifestyle change".
So yes, if this works for some people and helps them live better, good for them, and I really hope they thrive on this.
heck, I'm sitting in a team with a code base so full of slop that was written by humans, the AI can't even fix it and I'm burned out from trying to make it better. and I get told to be quiet about code standards because the team is still learning.
Fuck cancer.